Louisville, situated on the Ohio River, is influenced by both Southern and Midwestern culture. Louisville is home to a number of annual cultural events, of which the most well-known is the Kentucky Derby, held at the historical Churchill Downs. The Derby is preceded by a two-week long Kentucky Derby Festival comprised of over 70 events, starting with the annual Thunder Over Louisville, the largest annual fireworks display in the nation. Recently, Louisville has emerged as a major center for the health care and medical sciences industries. Louisville has been central to advancements in heart and hand surgery as well as cancer treatment.
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